Related Experiment Videos
Factor X deficiency in a cat
J L Gookin1, M B Brooks, J L Catalfamo
1Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
Journal of the American Veterinary Medical Association
|September 18, 1997
Summary
Severe congenital factor X deficiency, a rare bleeding disorder, was diagnosed in a domestic shorthair cat. This finding highlights the need for specific coagulation factor analysis in diagnosing feline coagulopathies.
Area of Science:
- Veterinary Medicine
- Hematology
- Genetics
Background:
- Congenital factor X deficiency is a rare inherited bleeding disorder affecting multiple species.
- Coagulopathies in cats can present with diverse clinical signs, complicating diagnosis.
Observation:
- A 3-year-old domestic shorthair cat presented with generalized seizures and prolonged bleeding post-venipuncture.
- Screening tests revealed a prolonged Russell's viper venom time in the dam and reduced factor X activity in the dam and a sibling.
Findings:
- The study reports the first known case of severe congenital factor X deficiency in a domestic cat.
- Evidence suggests a hereditary basis for factor X deficiency in this feline family.
Implications:
- This case expands the known spectrum of inherited coagulopathies in domestic animals.
- Accurate diagnosis of feline bleeding disorders may necessitate advanced coagulation factor analysis beyond standard screening tests.