Immunohistochemical demonstration of transferrin and transferrin receptor in mammalian integument

The present study demonstrates the distribution of transferrin and the transferrin receptor in the integument of eleven wild mammalian species using immunohistochemical methods. Both substances were regularly found in or near the peripheral cells of the sebaceous glands, especially of dense-haired animals. The transferrin receptor was also detectable in the epidermis, the secretory portion of tubular apocrine glands, and the outer epithelium of primary hair follicles. Transferrin as well as the transferrin receptor reacted strongly in macrophages of the papillary dermis only in the common seal. The results obtained are discussed with regard to possible biological functions in the skin of the substances demonstrated.