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[Decrease of intestinal absorption of 47-calcium in chronic alcoholism]

J F Vodoz, M Luisier, A Donath

    Schweizerische Medizinische Wochenschrift
    |October 29, 1977
    PubMed
    Summary
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    Chronic alcohol use significantly reduces intestinal calcium absorption, even without liver cirrhosis. This finding highlights a critical nutritional deficiency in alcoholism impacting bone health.

    Area of Science:

    • Gastroenterology
    • Nutritional Science
    • Endocrinology

    Context:

    • Chronic alcohol consumption is prevalent and associated with numerous health complications.
    • Calcium absorption is vital for bone health and overall metabolic function.
    • The impact of alcoholism on intestinal calcium absorption requires further elucidation, particularly differentiating between cirrhotic and non-cirrhotic states.

    Purpose:

    • To investigate and quantify intestinal calcium absorption in chronic alcoholics, comparing those with and without hepatic cirrhosis.
    • To establish reference ranges for intestinal calcium absorption in healthy individuals and correlate these with body weight and serum albumin.
    • To determine if chronic alcoholism itself, independent of cirrhosis, impairs calcium absorption.

    Summary:

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  • This study assessed intestinal calcium absorption using 47-calcium in 34 chronic alcoholics (17 cirrhotic, 17 non-cirrhotic) and 44 healthy controls.
  • In healthy controls, calcium absorption correlated negatively with body weight and positively with serum albumin.
  • Intestinal calcium absorption was significantly lower in both cirrhotic and non-cirrhotic alcoholics compared to controls, indicating alcohol's direct detrimental effect.

    • Impact:

    • Reveals that chronic alcoholism impairs intestinal calcium absorption irrespective of liver cirrhosis.
    • Suggests a potential mechanism for bone density loss and metabolic disturbances in alcoholics.
    • Underscores the need for nutritional interventions focusing on calcium absorption in alcohol use disorder treatment programs.