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[Serum digoxin concentration: dependence on body weight and age]
Schweizerische Medizinische Wochenschrift
|November 26, 1977
Summary
Digoxin serum concentrations correlate with body weight, age, and creatinine clearance in patients. Simplified formulas predict digoxin levels and maintenance doses for optimal therapeutic outcomes.
Area of Science:
- Pharmacology
- Clinical Chemistry
Context:
- Radioimmunoassay (RIA) was used to measure digoxin serum concentrations in 121 patients.
- Exclusion criteria included concurrent medications interfering with digoxin or elevated serum creatinine.
- Digoxin maintenance doses were adjusted based on body weight.
Purpose:
- To investigate the relationship between digoxin serum concentrations and patient factors like body weight, age, and renal function.
- To develop predictive formulas for digoxin serum levels and optimal maintenance doses.
Summary:
- Inverse proportionality was observed between digoxin concentration (per 0.25 mg daily dose) and body weight in patients aged 40-69.
- A weak positive correlation was found between digoxin concentration (per 0.25 mg daily dose and per 69.28 kg body weight) and age across all age groups (20-89 years).
- Positive correlations were also noted between digoxin concentration (per 0.25 mg daily dose) and creatinine clearance within the normal serum creatinine range.
Impact:
- Development of two simplified formulas to predict serum digoxin concentration and therapeutic maintenance dose.
- Formulas are applicable for patients with normal serum creatinine and digoxin tablets of optimal bioavailability.
- Aids in optimizing digoxin therapy and minimizing variability in serum concentrations.