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Related Experiment Videos

E-cadherin expression in upper-urinary-tract carcinoma

K Nakanishi1, T Kawai, C Torikata

  • 1Division of Environmental Medicine, National Defense Medical College Research Institute, Tokorozawa City, Japan.

International Journal of Cancer
|August 22, 1997
PubMed
Summary

E-cadherin (E-CD) immunoreactivity in upper urinary tract transitional-cell carcinoma (TCC-UUT) showed associations with stage, grade, and growth pattern. However, only tumor stage significantly impacted prognosis in multivariate analysis, limiting E-CD

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Area of Science:

  • Urothelial Carcinomas
  • Oncology
  • Cancer Biomarkers

Background:

  • Upper urinary tract transitional-cell carcinoma (TCC-UUT) is rare, with limited large-scale studies on prognosis.
  • E-cadherin (E-CD) is a cell adhesion molecule potentially involved in cancer progression.

Purpose of the Study:

  • To investigate the relationship between E-cadherin (E-CD) immunoreactivity and clinicopathological features and outcomes in TCC-UUT.
  • To assess the prognostic value of E-CD in TCC-UUT.

Main Methods:

  • Evaluated E-CD immunoreactivity in 154 TCC-UUT samples.
  • Correlated E-CD status with clinicopathological parameters (stage, grade, growth pattern).
  • Analyzed survival data (disease-free and overall survival) using univariate and multivariate analyses.

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Main Results:

  • "Normal" E-CD pattern observed in 29.2% of TCC-UUT cases.
  • E-CD immunoreactivity significantly correlated with stage, grade, and growth pattern.
  • Univariate survival analysis indicated E-CD, stage, grade, and growth pattern affected prognosis.
  • Multivariate analysis revealed only tumor stage was a significant independent prognostic factor for both disease-free and overall survival.

Conclusions:

  • E-cadherin (E-CD) immunoreactivity is associated with certain clinicopathological features in TCC-UUT.
  • E-CD status has limited value for predicting prognosis in TCC-UUT.
  • Tumor stage remains the primary prognostic indicator for TCC-UUT.