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Peripheral neuropathy and testosterone

R D Dickerman1, E Kramer, R Pertusi

  • 1Department of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth 76107-2609, USA.

Neurotoxicology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Elite bodybuilder experienced muscle atrophy and weakness after a testosterone injection. This case highlights potential neurotoxic effects of unsupervised androgen use.

Area of Science:

  • Sports Medicine
  • Neurology
  • Endocrinology

Background:

  • Anabolic-androgenic steroid (AAS) abuse is prevalent in bodybuilding.
  • Self-administration of intramuscular injections carries inherent risks.
  • Potential complications include local tissue damage and neurological deficits.

Observation:

  • A 265 lb male elite bodybuilder developed focal muscle atrophy in the vastus lateralis muscle.
  • Atrophy occurred within a month following a painful, self-administered testosterone injection.
  • The subject experienced paresthesia and a 40% loss of strength in the affected leg.

Findings:

  • The observed muscle atrophy and paresthesia suggest a neurological complication, possibly neuropraxia.
  • This may result from the direct neurotoxic effects of androgens or pressure from the injected fluid.

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  • Sensory or motor function was initially preserved, with deficits developing over days to weeks.

    • Implications:

    • This case underscores the potential neurotoxicity of androgens when used without medical supervision.
    • Unsupervised androgen use presents significant health risks beyond expected physiological effects.
    • Clinicians should be aware of these potential complications when evaluating patients using AAS.