Body weight: reduction by long-term glycerol treatment

Elevation of body glycerol concentration by multiple daily injections of glycerol was shown to lead to hypophagia and body weight loss followed by normal food intake and normal rate of body weight increase in rats. Termination of injections was followed by hyperphagia and an accelerated rate of growth. These findings suggest that the blood glycerol concentration plays an important role in the control of body weight and may be one signal by which the central nervous system monitors body lipid content.