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Adjuvant chemotherapy using cisplatin by subcutaneous administration

W S Dernell¹, S J Withrow, R C Straw

¹Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.

In Vivo (Athens, Greece)

|July 1, 1997

Summary

Subcutaneous cisplatin in dogs showed toxicity and slow systemic absorption. A drug delivery vehicle may be needed for sustained release and reduced adverse effects in cancer treatment.

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Area of Science:

Veterinary Medicine
Pharmacology
Oncology

Background:

Previous polymer release studies informed this investigation.
Evaluating novel drug delivery for cancer therapy is crucial.

Purpose of the Study:

To assess the toxicity, efficacy, and systemic absorption of subcutaneous cisplatin in dogs.
To determine the feasibility of using subcutaneous cisplatin as an adjunct cancer treatment.

Main Methods:

Six dogs with sarcoma received 50-70 mg/m2 cisplatin suspended in saline via subcutaneous injection.
Toxicity, serum platinum levels, and clinical outcomes were monitored post-administration.

Main Results:

Significant gastrointestinal, bone marrow, renal, and local tissue toxicity were observed.

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Measurable serum platinum levels persisted up to 14 days post-injection.

Treatments were discontinued due to toxicity, with dogs completing adjuvant therapy using intravenous carboplatin.

Conclusions:

Subcutaneous cisplatin administration in dogs resulted in considerable toxicity.
Slow systemic absorption of platinum occurred, but was associated with adverse effects.
A specialized drug delivery vehicle may be required for safe and effective sustained-release subcutaneous cisplatin therapy.