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Chitosan microcapsules as controlled release systems for insulin

K Aiedeh¹, E Gianasi, I Orienti

¹Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna, Italy.

Journal of Microencapsulation

|September 18, 1997

Summary

Researchers developed novel chitosan microcapsules for sustained insulin delivery. This innovative method ensures efficient insulin incorporation and controlled peptide release, offering a promising approach for drug formulation.

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Area of Science:

Biomaterials Science
Pharmaceutical Technology
Drug Delivery Systems

Background:

Chitosan is a versatile biopolymer with potential in drug delivery.
Developing controlled release systems for therapeutic peptides like insulin is crucial.
Surface crosslinked microparticulate systems offer advantages for encapsulating sensitive drugs.

Purpose of the Study:

To investigate the production of surface crosslinked chitosan microparticulate systems for insulin encapsulation.
To analyze the correlation between formulation parameters and microcapsule properties.
To evaluate the efficiency of insulin incorporation and the peptide release profile.

Main Methods:

Preparation of microcapsules using an innovative interfacial crosslinkage technique.

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Utilizing chitosan solubilized in the inner phase of a water/oil emulsion.

Employing ascorbyl palmitate for crosslinking and analyzing formulation parameters.

Main Results:

High efficiency of insulin incorporation into the microcapsules was achieved.
Sustained and constant peptide release was observed over extended periods.
Chitosan content significantly modulated the physico-chemical properties of the microcapsule matrix.

Conclusions:

Surface crosslinked chitosan microparticulate systems are effective for insulin encapsulation.
The formulation allows for controlled and sustained release of insulin.
This approach offers a promising strategy for developing advanced insulin delivery systems.