Related Experiment Videos
Alprazolam increases food intake in humans
M Haney1, S D Comer, M W Fischman
1Department of Psychiatry, College of Physicians and Surgeons of Columbia University, and New York State Psychiatric Institute, New York 10032, USA. mh235@columbia.edu
Psychopharmacology
|August 1, 1997
Summary
Alprazolam significantly increased daily caloric intake by nearly 1000 kcal in male participants. This medication also increased evening eating occasions without changing meal size or macronutrient composition.
Area of Science:
- Pharmacology
- Human Nutrition
- Behavioral Science
Background:
- Alprazolam is a benzodiazepine commonly prescribed for anxiety disorders.
- Understanding the side effects of psychotropic medications on eating behavior is crucial for patient management.
Purpose of the Study:
- To investigate the impact of alprazolam on total caloric intake and eating patterns in humans.
- To determine if alprazolam influences the timing, size, or macronutrient distribution of food consumption.
Main Methods:
- A controlled study involving seven male participants in a residential laboratory setting over 17 days.
- Administration of alprazolam (0.75 mg) or placebo at 1300 and 1730 hours, with food intake monitored.
- Comparison of food intake data on alprazolam administration days versus placebo and no-capsule days.
Main Results:
- Alprazolam administration led to a significant increase in total daily caloric intake, approximately 975 kcal above baseline.
- The number of eating occasions, particularly in the evening, was elevated following alprazolam administration.
- No significant alterations were observed in the size of eating occasions or the proportion of calories from carbohydrates, fat, and protein.
Conclusions:
- Alprazolam demonstrates a robust effect on increasing overall food consumption in humans.
- The medication appears to primarily influence the frequency of eating, especially during evening hours.
- These findings highlight the potential for alprazolam to affect appetite and eating behaviors, warranting consideration in clinical practice.