Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic processes shape spatiotemporal properties of retinal waves

M B Feller1, D A Butts, H L Aaron

  • 1Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.

Neuron
|August 1, 1997
PubMed
Summary

Spontaneous retinal waves in developing mammals, driven by cell networks, show complex patterns. A new model explains these patterns through random cell activation and local activity history.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular evidence of anteroposterior patterning in adult echinoderms.

Nature·2023
Same author

QTL associated with resistance to cassava brown streak and cassava mosaic diseases in a bi-parental cross of two Tanzanian farmer varieties, Namikonga and Albert.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2017
Same author

Heterogeneity of intrinsic biophysical properties among cochlear nucleus neurons improves the population coding of temporal information.

Journal of neurophysiology·2014
Same author

Climate change and the integrity of science.

Science (New York, N.Y.)·2010
Same author

The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome.

Proceedings of the National Academy of Sciences of the United States of America·2008
Same author

An instructive role for retinal waves in the development of retinogeniculate connectivity.

Neuron·2002

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Biology

Background:

  • Spontaneous waves of action potentials occur in the developing mammalian retina before vision.
  • These retinal waves originate from a network of amacrine and retinal ganglion cells.
  • The waves display complex spatiotemporal dynamics with shifting domains of coactivation.

Purpose of the Study:

  • To develop a novel dynamical model of retinal waves.
  • To quantitatively reproduce experimentally observed wave characteristics.
  • To elucidate the underlying mechanisms driving correlated activity in retinal waves.

Main Methods:

  • A novel dynamical model with two coupled cell populations was created.
  • The model was used to simulate retinal wave activity.

Related Experiment Videos

  • Model outputs were compared quantitatively with experimental data.

    • Main Results:

    • The model successfully reproduced experimentally observed domain sizes.
    • The model accurately predicted interwave intervals.
    • The model captured wavefront velocity profiles observed in experiments.
    • Both model and experimental data suggest a combination of random cell activation and local activity history explains correlated activity.

    Conclusions:

    • A two-population dynamical model can quantitatively explain retinal wave properties.
    • Retinal wave activity arises from a combination of stochastic cell activation and network memory.
    • This study provides a mechanistic understanding of early neural network development in the mammalian retina.