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Relationship between tissue mobilization and storage in the rat
C J Henry1, P R Payne, A Ghusain-Choueiri
1School of Biological and Molecular Sciences, Oxford Brookes University.
The British Journal of Nutrition
|July 1, 1997
Summary
This study investigated the protein (P) ratio in rats during fasting and refeeding. Results show individual P ratio values are characteristic, particularly in weanling rats, influencing protein mobilization and storage.
Area of Science:
- Animal physiology
- Nutritional science
- Metabolic research
Background:
- The P ratio quantifies protein's role in energy mobilization/storage.
- Understanding individual P ratio variations is crucial for metabolic studies.
Purpose of the Study:
- To investigate the P ratio in young and adult rats during fasting and refeeding.
- To determine if individual P ratio values are consistent across different metabolic states.
Main Methods:
- Rats (weanling and adult) underwent a 3-day fast followed by 17 days of refeeding.
- Body composition (fat and lean tissue) changes were measured to calculate Pfast and Prefed.
- Linear relationships between weight, energy, and nitrogen changes were used for calculations.
Main Results:
- Adult rats showed similar Pfast and Prefed values, with individual values correlated.
- Weanling rats exhibited a significantly higher Prefed compared to Pfast (2.5x).
- Individual Pfast and Prefed values were correlated in weanling rats.
Conclusions:
- Individual P ratio values appear characteristic, reflecting consistent protein mobilization/storage tendencies.
- Findings support the Payne-Dugdale model's predictions regarding individual metabolic traits.
- Age-related differences in P ratio dynamics were observed during fasting and refeeding.