Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoantibody screening for infertility: explaining the unexplained?

H H Hatasaka1, D W Branch, W H Kutteh

  • 1Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, USA.

Journal of Reproductive Immunology
|September 18, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with first thrombosis in patients presenting with obstetric antiphospholipid syndrome (APS) in the APS Alliance for Clinical Trials and International Networking Clinical Database and Repository: a retrospective study.

BJOG : an international journal of obstetrics and gynaecology·2018
Same author

Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study.

Lupus·2018
Same author

Bleeding complications and antithrombotic treatment in 264 pregnancies in antiphospholipid syndrome.

Lupus·2018
Same author

Preconception antiphospholipid antibodies and risk of subsequent early pregnancy loss.

Lupus·2018
Same author

Comparative study of 0° X-cut and Y + 36°-cut lithium niobate high-voltage sensing.

The Review of scientific instruments·2015
Same author

Laboratory evaluation of anti-phospholipid syndrome: a preliminary prospective study of phosphatidylserine/prothrombin antibodies in an at-risk patient cohort.

Clinical and experimental immunology·2014
Same journal

Successful live birth following immunomodulatory therapy in a patient with multiple recurrent pregnancy loss and massive perivillous fibrinoid deposition.

Journal of reproductive immunology·2026
Same journal

Circulating neutrophil extracellular traps and deoxyribonuclease in gestational diabetes mellitus.

Journal of reproductive immunology·2026
Same journal

Association between endometriosis and chronic endometritis: A retrospective cross-sectional study.

Journal of reproductive immunology·2026
Same journal

Inhibition of NHE1 induces trophoblast cell senescence via ADGRG6 mediated by CXCL8.

Journal of reproductive immunology·2026
Same journal

Combined spermidine and umbilical cord mesenchymal stem cell therapy repairs endometrial injury in mice via IL-10/Treg-Dependent immune microenvironment modulation.

Journal of reproductive immunology·2026
Same journal

Vaginal versus cervical types of visible fetal membranes in cervical insufficiency: Clinical characteristics and pathophysiology.

Journal of reproductive immunology·2026
See all related articles

Serum autoantibody testing for unexplained infertility and in vitro fertilization (IVF) lacks proven predictive value. Reviewing the justification for antiphospholipid antibody screening is crucial due to added costs.

Area of Science:

  • Reproductive medicine
  • Immunology
  • Clinical diagnostics

Background:

  • Serum autoantibody assays are offered by laboratories for unexplained infertility and in vitro fertilization (IVF).
  • The implication is that these tests predict treatment outcomes and guide clinical management.
  • Antiphospholipid antibody screening adds significant expense to fertility treatments.

Purpose of the Study:

  • To review the justification for using serum autoantibody panels in infertility screening.
  • To evaluate the predictive value of these assays for infertility treatment outcomes.
  • To assess the clinical utility and cost-effectiveness of antiphospholipid antibody screening.

Main Methods:

  • Literature review of studies on autoantibody assays in infertility.

Related Experiment Videos

  • Analysis of existing clinical guidelines and expert opinions.
  • Cost-benefit analysis of antiphospholipid antibody screening in IVF.

    • Main Results:

    • Current evidence does not consistently support the predictive value of routine autoantibody panels for infertility treatment success.
    • The clinical management is often not altered based on these screening results.
    • The added cost of antiphospholipid antibody screening may outweigh demonstrated benefits.

    Conclusions:

    • The routine use of serum autoantibody panels, including antiphospholipid antibodies, for unexplained infertility and IVF requires re-evaluation.
    • Stronger evidence is needed to justify the predictive value and clinical utility of these tests.
    • Alternative diagnostic and management strategies should be considered to optimize patient care and resource allocation.