Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymeric controlled delivery for immunization

R M Kuntz1, W M Saltzman

  • 1School of Chemical Engineering, Cornell University, Ithaca, NY 14853, USA. rmk14@cornell.edu

Trends in Biotechnology
|September 18, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.

Molecular cancer therapeutics·2024
Same author

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications.

Nature communications·2022
Same author

[In Process Citation].

Aktuelle Urologie·2015
Same author

Nerve growth factor delivery and cell aggregation enhance choline acetyltransferase activity after neural transplantation.

Tissue engineering·2009
Same author

Initial evaluation of the use of USPIO cell labeling and noninvasive MR monitoring of human tissue-engineered vascular grafts in vivo.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2008
Same author

Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model.

Biomaterials·2008
Same journal

A caspase-3-activated protein expression system for apoptosis visualization and apoptosis-pyroptosis conversion to boost antitumor activity.

Trends in biotechnology·2026
Same journal

Over 4 months of ethylene production using solid-state photosynthetic cell factories.

Trends in biotechnology·2026
Same journal

Closing the nitrogen loop in groundwater with biohybrid technologies.

Trends in biotechnology·2026
Same journal

Engineering environmental bacteria for whole-cell PET hydrolysis and assimilation.

Trends in biotechnology·2026
Same journal

Acoustic cavitation-enhanced lymphatic trafficking of inhaled bacterial-sourced biohybrid vaccines for antitumor immunity.

Trends in biotechnology·2026
Same journal

Make uphill thermodynamics downhill in pathway design.

Trends in biotechnology·2026
See all related articles

New polymeric delivery systems offer long-lasting protection with single-dose vaccines, overcoming current limitations in achieving systemic and mucosal immunity. This technology shows promise for significant global public health impact.

Area of Science:

  • Biomaterials science
  • Immunology
  • Vaccinology

Background:

  • Current vaccines often require multiple administrations for sustained immunity.
  • Achieving robust immunity at mucosal surfaces remains a challenge for conventional vaccine platforms.

Purpose of the Study:

  • To evaluate the potential of polymeric controlled-release systems for vaccine delivery.
  • To assess the efficacy of these systems in inducing long-lasting systemic and mucosal immunity.

Main Methods:

  • Utilized polymeric controlled-release systems and polymeric microspheres for vaccine delivery in animal models.
  • Administered polymeric devices delivering antibodies for passive immunity against genital herpes in mice.
  • Investigated orally administered polymeric-microsphere-based vaccines in rodents and primates.

Related Experiment Videos

Main Results:

  • Polymeric systems demonstrated the capacity for long-lasting immunoprotection, both systemically and mucosally, after single administration in animal models.
  • Antibody-eluting polymeric devices conferred passive immunity against genital herpes in mice.
  • Oral polymeric-microsphere vaccines elicited enhanced immune responses in rodents and primates.

Conclusions:

  • Polymeric controlled-release technologies offer a promising alternative to conventional vaccines, potentially enabling single-administration, long-lasting immunity.
  • These advanced delivery systems can induce both systemic and mucosal immunity, addressing key limitations of current vaccines.
  • The successful application of these technologies in humans could significantly advance global public health initiatives.