Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SSRIs and hyponatraemia

R M Lane1

  • 1Pfizer Pharmaceuticals Group, Pfizer Inc., New York, NY 10017-5755, USA.

The British Journal of Clinical Practice
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Elderly patients, especially females on SSRIs like fluoxetine, face a risk of hyponatremia. Monitor serum sodium levels in the initial weeks of treatment for unexplained symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letters.

The Physician and sportsmedicine·2016
Same author

BCL-2 is dispensable for thrombopoiesis and platelet survival.

Cell death & disease·2015
Same author

Forced titration as a confound in an SSRI comparator study of sertaline versus citalopram in the treatment of major depressive disorder.

Biological psychiatry·2001
Same author

Sertraline treatment of generalized social phobia: a 20-week, double-blind, placebo-controlled study.

The American journal of psychiatry·2001
Same author

Treatment of dysthymia with sertraline: a double-blind, placebo-controlled trial in dysthymic patients without major depression.

The Journal of clinical psychiatry·2000
Same author

Prevention of relapse in generalized social phobia: results of a 24-week study in responders to 20 weeks of sertraline treatment.

Journal of clinical psychopharmacology·2000
Same journal

Self-expandable oesophageal stents in the management of benign peptic oesophageal strictures in the elderly.

The British journal of clinical practice·1997
Same journal

Cerebral venous thrombosis occurring during an ectopic pregnancy and complicated by intracranial hypertension.

The British journal of clinical practice·1997
Same journal

Use of sympathomimetic nasal spray in association with cardiac fibroma: an unusual cause of ventricular tachycardia.

The British journal of clinical practice·1997
Same journal

Superior mesenteric vein occlusion presenting with a massive vascular malformation of the colon.

The British journal of clinical practice·1997
Same journal

Misdiagnoses in a Chinese narcoleptic patient with delayed onset of cataplexy.

The British journal of clinical practice·1997
Same journal

Tumour presenting as a retrosternal abscess following median sternotomy.

The British journal of clinical practice·1997
See all related articles

Area of Science:

  • Geriatric Medicine
  • Clinical Pharmacology
  • Endocrinology

Background:

  • Hyponatremia risk factors include advanced age, diuretics, and certain medical conditions.
  • Psychotropic medications, including TCAs, MAOIs, and SSRIs, are implicated in hyponatremia development.
  • The exact causative role of most psychotropic drugs is not established, with effects often being idiosyncratic.

Purpose of the Study:

  • To review the association between SSRIs and hyponatremia in elderly patients.
  • To highlight the risk factors and timing of SSRI-induced hyponatremia.
  • To emphasize the importance of monitoring serum sodium levels in at-risk populations.

Main Methods:

  • Literature review of case reports and studies on SSRI-induced hyponatremia.

Related Experiment Videos

  • Analysis of patient demographics, co-medications, and clinical presentation.
  • Estimation of hyponatremia frequency in specific patient groups.

    • Main Results:

    • SSRIs are associated with hyponatremia, particularly in elderly females over 70.
    • Concomitant diuretic therapy is a common factor in reported cases.
    • The incidence of hyponatremia with fluoxetine in elderly females may be up to 8 per 1000, with highest risk in the first few weeks of treatment.

    Conclusions:

    • Elderly patients on SSRIs, especially females, require careful monitoring for hyponatremia.
    • Early detection through serum sodium level measurement is crucial during the initial treatment phase.
    • Unexplained symptoms in elderly patients on SSRIs warrant prompt investigation for hyponatremia.