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Pigmented squamous cell carcinoma with dendritic melanocytes
The Australasian Journal of Dermatology
|August 1, 1997
Summary
A pigmented skin lesion on the ear was diagnosed as a rare variant of squamous cell carcinoma. This unusual presentation involved atypical keratinocytes and numerous melanocytes, mimicking malignant melanoacanthoma.
Area of Science:
- Dermatopathology
- Oncology
- Dermatology
Background:
- Squamous cell carcinoma (SCC) is a common skin cancer.
- Pigmented variants of SCC are rare.
- Malignant melanoacanthoma is a rare entity that can mimic pigmented SCC.
Observation:
- A 79-year-old man presented with a pigmented nodule on his right ear.
- Epiluminescence microscopy showed a diffuse grey-blue color.
- Skin biopsy revealed invasive squamous cell carcinoma with numerous dendritic melanocytes.
Findings:
- The tumor exhibited irregular acanthosis and lobular clusters of atypical keratinocytes invading the dermis.
- The presence of numerous dendritic melanocytes raised differential diagnostic considerations.
- The lesion was ultimately classified as an unusual variant of pigmented squamous cell carcinoma.
Implications:
- This case highlights the importance of considering pigmented SCC variants in dermatopathology.
- Accurate classification is crucial for appropriate clinical management and prognosis.
- Further research into the pathogenesis of pigmented SCC may improve diagnostic accuracy.