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[Hypertrophic cardiomyopathy showing no 123I-BMIPP myocardial accumulation with type I CD36 deficiency]
K Watanabe1, S Miyajima, Y Kusano
1Niigata College of Pharmacy.
Insights
This study investigates a patient with hypertrophic cardiomyopathy (HCM) and no myocardial uptake of 123I-beta-methyl-p-iodophenylpentadecanoic acid (123I-BMIPP). Researchers found type 1 CD36 deficiency may explain the lack of 123I-BMIPP uptake in the heart.
Area of Science:
- Cardiology
- Medical Imaging
- Genetics
Background:
- Hypertrophic cardiomyopathy (HCM) is a genetic heart condition.
- Myocardial fatty acid metabolism is crucial for cardiac function.
- 123I-beta-methyl-p-iodophenylpentadecanoic acid (123I-BMIPP) is used to assess myocardial fatty acid uptake.
Observation:
- A 57-year-old male with HCM presented with chest oppression and shortness of breath.
- 201Tl SPECT showed regional increased accumulation in the ventricular septum.
- No myocardial accumulation of 123I-BMIPP was observed in this patient.
Findings:
- The patient was diagnosed with type 1 CD36 deficiency.
- CD36 is a key transporter for myocardial uptake of long-chain fatty acids.
- This deficiency correlates with the absence of 123I-BMIPP myocardial uptake.
Implications:
- CD36 deficiency may be a contributing factor to impaired myocardial fatty acid metabolism in HCM.
- This finding could refine the interpretation of 123I-BMIPP SPECT in patients with cardiac conditions.
- Further research is warranted to explore the role of CD36 in cardiac pathophysiology and diagnostic imaging.
Abstract:
A 57 years old male consulted our hospital in complaining chest oppression and short of breath. Familial and dilated phase hypertrophic cardiomyopathy (HCM) was detected by ECG, echocardiography, left ventriculography and left ventricular endomyocardial biopsy. 201T1 SPECT showed regional increased accumulation in the ventricular septum, however, no myocardial accumulation of 123I-beta-methyl-p-iodophenylpentadecanoic acid (123I-BMIPP) was observed. We analyzed CD36 in this patient, and found he had type 1 CD36 deficiency. Myocardial uptake of long-chain fatty acids occurs via a specific transporter, which is homologous with human CD36. We hypothesize that CD36 deficiency, especially type 1 CD36 deficiency, might be one factor of no myocardial 123I-BMIPP uptake.