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Related Experiment Videos

Upper extremity versus lower extremity deep venous thrombosis

A Hingorani1, E Ascher, J Hanson

  • 1Department of Surgery, Maimonides Medical Center, Brooklyn, New York 11219, USA.

American Journal of Surgery
|August 1, 1997
PubMed
Summary

Upper extremity deep venous thrombosis (UEDVT) is often underestimated, but this study found it carries higher risks of pulmonary embolism and mortality compared to lower extremity deep venous thrombosis (LEDVT). UEDVT is an underrecognized predictor of severe outcomes.

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Area of Science:

  • Vascular Medicine
  • Thrombosis Research
  • Clinical Outcomes

Background:

  • Upper extremity deep venous thrombosis (UEDVT) is traditionally considered less severe than lower extremity deep venous thrombosis (LEDVT).
  • Previous beliefs suggested minimal morbidity or mortality associated with UEDVT.

Purpose of the Study:

  • To compare the incidence of pulmonary embolism and mortality between UEDVT and LEDVT.
  • To challenge the prevailing notion of UEDVT's low associated risk.

Main Methods:

  • Retrospective review of medical records and patient interviews.
  • Analysis of 430 patients with LEDVT and 52 patients with UEDVT.
  • Data collected between January 1994 and June 1995.

Main Results:

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  • Pulmonary embolism occurred in 17% of UEDVT patients versus 8% of LEDVT patients (P <0.05).
  • Six-month mortality was significantly higher in UEDVT patients (48%) compared to LEDVT patients (13%) (P <0.0002).

Conclusions:

  • Contrary to prior assumptions, UEDVT is associated with significantly higher morbidity and mortality than LEDVT.
  • UEDVT should be recognized as an underappreciated predictor of adverse health outcomes.