Related Experiment Videos
Intestinalization of gastric signet ring cell carcinomas with progression
T Yamachika1, K Inada, Y Fujimitsu
1Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Virchows Archiv : an International Journal of Pathology
|August 1, 1997
Summary
Gastric signet ring cell carcinoma progression involves a shift from gastric to intestinal cell phenotypes. This phenotypic change correlates with increased invasion depth in gastric tumors.
Area of Science:
- Gastroenterology
- Oncology
- Cell Biology
Background:
- Recent advances in mucin histochemistry and immunohistochemistry enable phenotype determination in gastric carcinoma.
- Phenotypic plasticity is observed, with gastric epithelial cells changing to intestinal types during tumor growth in animal models.
Purpose of the Study:
- To investigate cell differentiation and phenotypic expression in gastric signet ring cell carcinomas.
- To correlate phenotypic changes with tumor invasion depth and progression.
Main Methods:
- Analysis of 203 surgically obtained gastric signet ring cell carcinoma specimens.
- Histochemical and immunohistochemical assessment of gastric and intestinal epithelial cell phenotypes.
Main Results:
- Gastric phenotype carcinomas decreased with invasion depth.
- Mixed phenotype carcinomas increased with invasion depth.
- Intestinal phenotype was rare (2%) and associated with serosal involvement.
Conclusions:
- Gastric signet ring cell carcinoma progression is linked to a phenotypic shift from gastric to intestinal expression.
- The degree of invasion correlates with changes in cellular phenotype.