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[Correlation between the tumor marker Pro-GRP and prognosis in patients with small-cell lung cancer]

T Tsuchiyama¹, M Kawahara, N Naka

¹Department of Internal Medicine, National Kinki Central Hospital for Chest Diseases, Osaka, Japan.

Nihon Kyobu Shikkan Gakkai Zasshi

|June 1, 1997

Abstract:

We studied 90 patients with small-cell lung cancer in whom levels of Pro-GRP were abnormally high before therapy. Changes in the serum Pro-GRP level have been said to correlate strongly with therapeutic responses in patients with small-cell lung cancer. We found that changes in the serum Pro-GRP level (half-life > or = 30 vs < 30 days) were a significant prognostic factor. Multivariate analysis showed that in these patients the Pro-GRP level after therapy, Performance Status, and age were independent prognostic factors.

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