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[Hypercoagulable state in Duchenne muscular dystrophy]

Y Saito1, T Komiya, M Kawai

  • 1Department of Neurology, Shimoshizu National Hospital.

Rinsho Shinkeigaku = Clinical Neurology
|May 1, 1997
PubMed
Summary

Duchenne muscular dystrophy (DMD) patients frequently exhibit a hypercoagulable state, indicated by abnormal coagulation markers. This suggests inherent factors and immobility contribute to thrombosis risk in DMD.

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Area of Science:

  • Hematology
  • Neurology
  • Genetics

Context:

  • Duchenne muscular dystrophy (DMD) is associated with life-threatening pulmonary and cerebral infarctions.
  • The hypercoagulable state in DMD patients requires further investigation into its underlying mechanisms.

Purpose:

  • To investigate coagulation and fibrinolysis markers in DMD patients to understand the hypercoagulable state.
  • To identify factors contributing to thrombosis risk in Duchenne muscular dystrophy.

Summary:

  • 69 DMD patients and 50 controls were assessed for coagulation markers, including thrombotest, thrombin-antithrombin III complex (TAT), and alpha 2-plasmin inhibitor plasmin complex (PIC).
  • 96% of DMD patients showed abnormal coagulation results, with low thrombotest (78%), high TAT (61%), and high PIC (40.3%) being frequent.
  • Abnormalities were not correlated with age, daily living activities, or cardiac/respiratory function, but were more prevalent in DMD patients than controls.

Impact:

  • Findings suggest inherent factors, immobilization, and cardiac dysfunction contribute to the hypercoagulable state in Duchenne muscular dystrophy.
  • This research highlights the need for proactive management of thrombosis risk in DMD patients.

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