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Lymphangiomas of the oral cavity: a clinicopathologic, immunohistochemical, and electron-microscopic study
T D Brennan1, A S Miller, S Y Chen
1Hospital of the University of Pennsylvania, Philadelphia, USA.
Purpose:
This study evaluated the demographics, treatment outcomes, histology, and basement lamina characteristics of a large series of lymphangiomas.
Material And Methods:
Forty-seven lymphangiomas of the oral cavity were evaluated microscopically and representative specimens were also evaluated immunohistochemically (IMH) and by electron microscopy (EM).
Results:
Patient's ages ranged from 2 to 84 years. The dorsal surface of the tongue was the most common site. Discontinuities in the basement membrane were detected with IMH and EM.
Conclusion:
The discontinuous basement membrane may explain why sclerosing agents have not been effective as a form of treatment for lymphangioma.