Related Experiment Video
Updated: Aug 13, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Synovial sarcoma: frequency of nonaggressive MR characteristics
M F Blacksin1, J R Siegel, J Benevenia
1Department of Radiology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA.
Synovial sarcoma can present with nonaggressive MRI features, particularly smaller lesions (<5 cm) that appear well-circumscribed and homogeneous. Larger tumors often show heterogeneous characteristics, aiding in diagnosis.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Synovial sarcoma is a rare soft tissue malignancy.
- Accurate pre-operative diagnosis is crucial for appropriate management.
- Magnetic Resonance (MR) imaging plays a key role in soft tissue tumor evaluation.
Purpose of the Study:
- To characterize the MR appearance of synovial sarcoma.
- To determine the prevalence of a nonaggressive imaging presentation in synovial sarcoma.
Main Methods:
- Retrospective analysis of MR examinations from 15 patients with confirmed synovial sarcoma.
- Evaluation of imaging features including size, margins, homogeneity, internal architecture, signal intensity (T1 and T2 weighted), and bone invasion.
Main Results:
- 33% of lesions (5/15) were small (<5 cm), well-circumscribed, and homogeneous, with specific T1 and T2 signal intensities.
- Larger lesions (10/15, mean length 11.3 cm) exhibited increased heterogeneity and variable margins.
Conclusions:
- Synovial sarcoma can present with two distinct MR imaging patterns.
- Small, homogeneous lesions may mimic benign masses, potentially leading to suboptimal surgical approaches.
- Larger lesions are typically more heterogeneous, aiding in differentiation.
More Related Videos
09:33Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
Published on: August 25, 2023
08:57Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Related Concept Videos
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...