Rheumatoid nodules: MR/pathological correlation
Related Experiment Video
Updated: Aug 7, 2026

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
Published on: October 20, 2013
K I el-Noueam1, V Giuliano, M E Schweitzer
1Department of Radiology, Alexandria University, Egypt.
Purpose:
To demonstrate the signal characteristics of subcutaneous rheumatoid nodules in correlation to their histopathologic features.
Method:
The magnetic resonance imaging (MRI) features of biopsy proven subcutaneous rheumatoid nodules are described in five patients with rheumatoid arthritis established by classic criteria.
Results:
Two morphologic appearances of rheumatoid nodules were observed on MRI: one predominantly cystic, with enhancing peripheral component; and a second type which is predominantly solid, with uniform enhancement following gadolinium injection.
Conclusion:
Subcutaneous rheumatoid nodules can appear by MR as solid, cystic, or a combination of both components. This closely correlates with their histopathologic evolution.
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