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Vortex keratopathy in a patient with multiple myeloma
E M Chong1, R J Campbell, W M Bourne
1Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 53905, USA.
Purpose:
We report a 52-year-old woman with vortex keratopathy (cornea verticillata) of unknown cause in whom multiple myeloma was found 18 months later.
Methods:
Surgical biopsy of conjunctival crystalline deposits, which were stained immunohistologically and analyzed ultrastructurally, as well as hematologic workup for multiple myeloma, were performed.
Results:
Light microscopy of conjunctival deposits revealed plasmacytoid infiltrates in the conjunctiva, which stained monoclonally for immunoglobulin G (IgG)-kappa light chains. Transmission electron microscopy showed intracellular hexagonal crystalline structures and extracellular microfibrils. Hematologic tests confirmed the diagnosis of multiple myeloma.
Conclusion:
Multiple myeloma is one of the many causes of vortex keratopathy.