Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal thyroxine and elevated thyrotropin concentrations: evolving hypothyroidism or persistent euthyroidism with

U M Kabadi1, R Cech

  • 1VA Medical Centers, Des Moines Iowa, USA.

Journal of Endocrinological Investigation
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Comparison of optical and ultrasound biometry and assessment of using both methods in practice].

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti·2014
Same author

[Assessment of postoperative anterior-posterior shift of AcrySof SP lens in time and its impact on resulting refraction].

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti·2014
Same author

RF-EMF exposure of fetus and mother during magnetic resonance imaging.

Physics in medicine and biology·2008
Same author

Assessment of inhomogeneous ELF magnetic field exposures.

Radiation protection dosimetry·2008
Same author

Current densities in a pregnant woman model induced by simultaneous ELF electric and magnetic field exposure.

Physics in medicine and biology·2008
Same author

Electric emissions from electrical appliances.

Radiation protection dosimetry·2007
Same journal

Delirium in diabetic ketoacidosis: a multicenter observational study of occurrence, associated factors and outcomes from 578,204 hospitalizations.

Journal of endocrinological investigation·2026
Same journal

Low work ability and high disability burden in Cushing's syndrome: a multicenter cohort study.

Journal of endocrinological investigation·2026
Same journal

Association of C-reactive protein to albumin ratio with progression of CKD and all-cause mortality in diabetic CKD.

Journal of endocrinological investigation·2026
Same journal

PMOS in black girls and women: from high to low risk.

Journal of endocrinological investigation·2026
Same journal

Inhibition of TGF-β1/Smad signaling reverses the dedifferentiated phenotype of thyroid cancer cells in three-dimensional culture.

Journal of endocrinological investigation·2026
Same journal

lncRNA PANDAR predicts adverse pregnancy outcomes and reflects hyperglycemia-associated cellular stress in gestational diabetes mellitus.

Journal of endocrinological investigation·2026
See all related articles

Individuals with elevated TSH but normal thyroid hormones may have inhibited pituitary function, leading to hypothyroidism. Others maintain normal thyroid function with a "reset thyrostat" for life.

Area of Science:

  • Endocrinology
  • Thyroidology

Background:

  • Elevated thyrotropin (TSH) with normal thyroxine (T4) and triiodothyronine (T3) presents two outcomes: progression to hypothyroidism or stable euthyroidism.
  • Current thyroid hormone levels do not predict these outcomes.

Purpose of the Study:

  • To investigate the role of the pituitary thyroid axis in subjects with normal T4/T3 and elevated TSH.
  • To differentiate between evolving hypothyroidism and a stable euthyroid state.

Main Methods:

  • Assessed 24-hour iodine-131 (131I) thyroidal uptake in 17 subjects with normal T4/T3 and elevated TSH.
  • Measured uptake response to subcutaneous bovine TSH and oral L-triiodothyronine (LT3).
  • Followed subjects for up to 16 years to observe natural progression.

Related Experiment Videos

Main Results:

  • Eight subjects showed blunted 131I uptake responses to TSH and LT3, progressing to hypothyroidism within two years.
  • Nine subjects exhibited normal 131I uptake responses, with only one developing hypothyroidism over 16 years.

Conclusions:

  • Subjects with normal T4/T3 and elevated TSH are not uniformly progressing to hypothyroidism.
  • Two distinct populations exist: one with an inhibited pituitary thyroid axis and another with a "reset thyrostat" maintaining euthyroidism.