Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic alkalosis

B F Palmer1, R J Alpern

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dalias 75235, USA.

Journal of the American Society of Nephrology : JASN
|September 19, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-shivering thermogenesis as a mechanism to facilitate sustainable weight loss.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption.

International journal of obesity (2005)·2015
Same author

Effectiveness of initiating treatment with valsartan/hydrochlorothiazide in patients with stage-1 or stage-2 hypertension.

Journal of human hypertension·2009
Same author

Impaired renal autoregulation: implications for the genesis of hypertension and hypertension-induced renal injury.

The American journal of the medical sciences·2001
Same author

Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis.

The Journal of clinical investigation·2001
Same author

Individualizing the dialysate in the hemodialysis patient.

Seminars in dialysis·2001

The kidney has many ways to prevent metabolic alkalosis. When these fail, it can cause serious health issues and requires aggressive treatment for patient survival.

Area of Science:

  • Nephrology
  • Renal Physiology
  • Acid-Base Balance

Background:

  • The kidney plays a crucial role in maintaining acid-base homeostasis.
  • Metabolic alkalosis occurs when the body's acid-base balance is disrupted, leading to an excess of bicarbonate.
  • Disruption of renal homeostatic mechanisms for bicarbonate excretion is central to persistent metabolic alkalosis.

Purpose of the Study:

  • To elucidate the renal mechanisms involved in preventing and correcting metabolic alkalosis.
  • To understand how kidney function perturbations lead to sustained metabolic alkalosis.
  • To improve clinical diagnosis and treatment strategies for patients with metabolic alkalosis.

Main Methods:

  • Review of established physiological mechanisms of renal bicarbonate handling.

Related Experiment Videos

  • Analysis of clinical scenarios involving impaired renal compensation for alkalosis.
  • Synthesis of current understanding of kidney's role in acid-base balance.

    • Main Results:

    • The kidney employs multiple sophisticated mechanisms to excrete excess bicarbonate and prevent metabolic alkalosis.
    • Failure of these renal mechanisms signifies a significant disruption in homeostasis.
    • Persistent metabolic alkalosis, though often manageable, can be life-threatening in specific clinical contexts.

    Conclusions:

    • Understanding the kidney's role in metabolic alkalosis is key to effective clinical management.
    • Disrupted renal compensation for alkalosis necessitates targeted diagnostic and therapeutic approaches.
    • Aggressive treatment of metabolic alkalosis is warranted when it poses a mortality risk.