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[Study on drawing aseptic gas in diluting drugs]
Zhonghua Hu Li Za Zhi = Chinese Journal of Nursing
|July 1, 1996
Summary
Aseptic gas from sealed bottles and alcohol lamps showed no bacterial contamination. In contrast, treatment room air contained bacteria, suggesting aseptic gas is preferable for drug dilution.
Area of Science:
- Microbiology
- Pharmaceutical Science
Background:
- Maintaining sterility is crucial in pharmaceutical preparations.
- Air quality in treatment rooms can impact microbial contamination.
Purpose of the Study:
- To assess the microbial load in different gas sources.
- To determine the suitability of various gas sources for drug dilution.
Main Methods:
- Bacterial cultures were performed on gases from sealed aseptic bottles, alcohol lamp flames, and treatment room air.
- Deactivated penicillin solutions were diluted with these gases and then cultured.
Main Results:
- No bacterial colonies were observed in gases from sealed aseptic bottles or alcohol lamp flames.
- Bacterial colonies were present in samples from the treatment room air.
Conclusions:
- Sealed aseptic gas sources are demonstrably sterile.
- Sterile gas should be sourced and stored for pharmaceutical drug dilution to prevent contamination.