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[Basedow's disease in an adolescent with histiocytosis X]
L Viollet1, M C Commare-Nordmann, J Langlais
1Service de pédiatrie, hôpital Raymond-Poincaré, Garches, France.
Background:
Immunological dysfunction is known to be present in Langerhans cell histiocytosis; some autoimmune diseases with autoantibodies associated with this condition have already been described. This immunological dysfunction could play a role in the Langerhans cell histiocytosis pathogenesis.
Case Report:
A 13 year-old boy presented a multifocal bone Langerhans cell histiocytosis associated with Graves' syndrome. This last condition was successfully treated with carbimazole while the focal lesions of histiocytosis did not require any treatment.
Conclusion:
This unique association could be explained by the immunological dysfunction seen in Langerhans cell histiocytosis with secondary appearance of thyreo-stimulating antibodies.