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Bradykinin-induced venodilation is not different in blacks
Z Vajo1, M McDonald, B Takahashi
1Department of Medicine, Maricopa Medical Center, Phoenix, Arizona 85008, USA.
British Journal of Clinical Pharmacology
|September 20, 1997
Summary
Young Black individuals do not show a decreased vasodilatory response to bradykinin compared to Whites. This finding suggests that impaired endothelium-derived relaxing factor (EDRF) response is not linked to hypertension prevalence in Black populations.
Area of Science:
- Cardiovascular Physiology
- Vascular Biology
- Racial Health Disparities
Background:
- Previous studies indicated a blunted venodilator response to isoprenaline in young, normotensive Black individuals compared to Whites.
- Hypertension prevalence is higher in Black populations, suggesting potential underlying vascular differences.
Purpose of the Study:
- To investigate whether young, normotensive Black individuals also exhibit a reduced vasodilatory response to bradykinin compared to their White counterparts.
- To explore the potential role of endothelium-derived relaxing factor (EDRF) in observed racial differences in vascular function.
Main Methods:
- A comparative study involving 11 Black and 11 White subjects.
- Bradykinin dose-response curves were generated in phenylephrine-preconstricted hand veins.
- Vascular responses were quantified by measuring changes in vein diameter.
Main Results:
- No significant difference was observed in the maximal vasodilatory response to bradykinin between Black and White subjects (P = NS).
- The dose of bradykinin required to achieve half-maximal response was similar in both racial groups (P = NS).
- No significant difference was found in the phenylephrine dose required to achieve 80% venous constriction between the groups.
Conclusions:
- The vasodilatory response to bradykinin is similar in young, normotensive Black and White individuals.
- Diminished vasodilatory response to endothelium-derived relaxing factor (EDRF) does not appear to be associated with the higher prevalence of hypertension in Black populations.