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Regionally different effects of scopolamine on NMDA antagonist-induced heat shock protein HSP70
S I Tomitaka1, K Hashimoto, N Narita
1Department of Cortical Function Disorder, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Abstract:
Using immunohistochemical technique, we investigated the regionally different roles of muscarinic receptors in the induction of HSP-70 by NMDA receptor antagonists. The administration of memantine and phencyclidine induced HSP-70 in the retrosplenial cortex of rat brain. Pretreatment with the muscarinic receptor antagonist scopolamine (0.1-1 mg/kg) blocked induction of HSP-70 in layer III of the retrosplenial cortex. However, induction of HSP-70 in layer V was augmented by scopolamine. These results suggest a regional difference in the mechanism of neurotoxicity induced by NMDA receptor antagonists.