Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis
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R M Duberley1, I P Johnson, P Anand
1Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London, UK.
Brain Research
|July 25, 1997
Abstract:
Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 microm), medium-(26-39 microm), and large-(> 40 microm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.