[Effects of PDGF AB on extracellular matrix synthesis by human mammary fibroblasts]

PDGF AB effect on extracellular matrix protein synthesis and release by a primary culture of non transformed human mammary fibroblasts was analyzed. Primarily PDGF AB induced a modified protein distribution, with a global enhancement of secreted proteins as compared to intracytoplasmatic proteins. Furthermore, an increase in synthesis and release of the extracellular matrix proteins such as fibronectin and type I and IV collagens upon PDGF AB treatment with specific immunoprecipitation was demonstrated.