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[Low birth weight as an additional indication for chromosomal analysis]
M L Martínez-Frías1, E Bermejo Sánchez, E Rodríguez Pinilla
1ECEMC, Facultad de Medicina, Universidad Complutense de Madrid.
Insights
Infants with chromosomal abnormalities, such as trisomy 18, often have low birth weights. This finding suggests that low birth weight in infants with anomalies warrants chromosomal analysis.
Area of Science:
- Genetics
- Pediatrics
- Epidemiology
Background:
- Low birth weight is commonly observed in infants with chromosomal abnormalities like trisomy 18 and trisomy 13.
- Limited epidemiological data exists on birth weights across various chromosomal abnormality groups.
Purpose of the Study:
- To analyze birth weights and gestational ages in a large cohort of malformed infants with chromosomal anomalies.
- To compare birth weights among different clinical groups of malformed infants.
Main Methods:
- Analysis of birth weights and gestational ages from 23,155 malformed infants and a comparable number of non-malformed infants.
- Stratification of data by specific chromosomal anomaly groups.
- Comparative analysis of birth weights within clinical groups.
Main Results:
- Infants with most chromosomal abnormalities exhibited significantly lower birth weights compared to control groups.
- Specific trends in birth weight were observed across different chromosomal anomaly classifications.
Conclusions:
- A strong association exists between chromosomal alterations and low birth weight.
- Low birth weight in infants presenting with minor or major anomalies should be considered an indicator for chromosomal analysis.
Introduction:
Even though there are few epidemiological studies evaluating the birth weights of different groups of malformed babies with chromosomal abnormalities, it is widely known that infants with trisomy 18, and to a lesser degree those with trisomy 13 and other chromosomal alterations, have low birth weights.
Patients And Methods:
In this study we present the analysis of the birth weights and gestational ages of a large sample of babies (23,155 malformed and a similar number of nonmalformed babies), separating the different groups of chromosomal anomalies and comparing the weight in the clinical groups of malformed infants.
Results:
Most of the groups with chromosomal abnormalities present lower birth weights in comparison to the other groups.
Conclusions:
The results of our study support the conclusion that the relationship between chromosomal alterations and low birth weight is sufficiently important that such a low birth weight in children with minor or major anomalies should be considered as one more indication to perform chromosomal analysis.