Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methodologic problems encountered with cooximetry in methemoglobinemia

S Rausch-Madison1, Z Mohsenifar

  • 1Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine, USA.

The American Journal of the Medical Sciences
|September 23, 1997
PubMed
Summary

Cooximetry accurately measures methemoglobin (MetHb) levels, crucial for diagnosing methemoglobinemia. When MetHb exceeds 10%, rely on cooximetry over pulse oximetry for accurate oxygen saturation readings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modified sleeve anastomosis in large muscular arteries of sheep.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2005
Same author

Aortic root dilatation in patients with emphysema.

American heart journal·2001
Same author

Use of forced inspiratory vital capacity to identify bronchodilator reversibility in obstructive lung disease.

The Journal of asthma : official journal of the Association for the Care of Asthma·2001
Same author

Motivating factors in futile clinical interventions.

Chest·2001
Same author

Measurement of gastric P(CO2) as an index of tissue hypoxia during obstructive sleep apnea.

Respiration; international review of thoracic diseases·2001
Same author

The value of a hospitalist service: efficient care for the aging population?

Chest·2001

Area of Science:

  • Clinical Chemistry
  • Critical Care Medicine
  • Toxicology

Background:

  • Methemoglobinemia, a condition where hemoglobin is oxidized, can impair oxygen transport.
  • Accurate assessment of methemoglobin (MetHb) levels is vital for patient management.
  • Pulse oximetry may provide inaccurate oxygen saturation readings in the presence of MetHb.

Observation:

  • Two patients with acute methemoglobinemia secondary to sulfa medications were analyzed.
  • Serial measurements of pulse oximetry, arterial blood gas, and cooximetry were performed.
  • Cooximetry revealed MetHb levels from 6% to 48%, with combined methemoglobin and oxyhemoglobin exceeding 100% in some cases.

Findings:

  • Cooximetry reported discrepant values, including negative carboxyhemoglobin, when MetHb levels were high.

Related Experiment Videos

  • Significant discrepancies were observed between pulse oximetry and arterial blood gas-derived oxygen saturations.
  • Pulse oximetry consistently underestimated oxygen saturation when MetHb levels were greater than 9%.

    • Implications:

    • Cooximetry is recommended for screening methemoglobinemia when MetHb levels exceed 10%.
    • Serial cooximetry measurements are essential for guiding therapy in methemoglobinemia.
    • Clinical decisions should not solely rely on noninvasive pulse oximetry in suspected or confirmed methemoglobinemia.