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Streptokinase, complement activation and hypotension

A Pachaï1, A K Erlendsson, I Brandslund

  • 1Department of Medicine, Vejle County Hospital, Denmark.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|August 1, 1997
PubMed
Summary

This study investigated if complement activation causes hypotension during streptokinase treatment for myocardial infarction. Results show hypotension occurred in all patients, unrelated to complement activation levels, leaving the mechanism unclear.

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Area of Science:

  • Cardiology
  • Immunology
  • Pharmacology

Background:

  • Streptokinase is used to treat acute myocardial infarction.
  • Transient hypotension is a known side effect of streptokinase infusion.
  • The underlying mechanism of this hypotension remains unclear.

Purpose of the Study:

  • To determine if complement activation causes transient hypotension during streptokinase infusion in acute myocardial infarction patients.

Main Methods:

  • Assessed complement activation using Complement 3d (C3d) levels in venous blood.
  • Measured blood pressure in thirteen patients receiving streptokinase for suspected acute myocardial infarction.
  • Correlated C3d levels and blood pressure changes.

Main Results:

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  • All thirteen patients experienced transient hypotension during streptokinase infusion.
  • Five patients showed a significant increase (>200%) in C3d levels within 30 minutes.
  • Hypotension was not correlated with the presence of myocardial infarction or the degree of complement activation.

Conclusions:

  • Complement activation does not appear to be the cause of transient hypotension during streptokinase infusion.
  • The mechanism by which streptokinase induces hypotension requires further investigation.