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Related Concept Videos

Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

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Correlation between admission laboratory values, early abdominal computed tomography, and severe complications of gallstone pancreatitis.

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Related Experiment Video

Updated: Jun 25, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
17:42

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Islet cell tumors

B E Stabile1

  • 1Department of Surgery, Harbor-UCLA Medical Center, Torrance 90509, USA.

The Gastroenterologist
|September 23, 1997
PubMed
Summary
This summary is machine-generated.

Islet cell tumors are rare but dangerous. Early diagnosis via clinical syndromes and peptide levels, followed by imaging and surgery, is crucial for effective treatment and improved outcomes.

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Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
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Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

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Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
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Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles

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Last Updated: Jun 25, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
17:42

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
08:04

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles

Published on: November 3, 2023

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Diagnostic Imaging

Background:

  • Islet cell tumors, though rare, pose significant clinical challenges due to diverse symptoms and high lethality.
  • Early diagnosis is critical for managing these tumors effectively.

Purpose of the Study:

  • To outline the diagnostic and therapeutic strategies for islet cell tumors.
  • To emphasize the importance of early recognition, accurate localization, and surgical intervention.

Main Methods:

  • Recognition of clinical syndromes and confirmation of elevated peptide levels via radioimmunoassay.
  • Medical management of hormonal syndromes using specific agents (e.g., diazoxide, omeprazole, octreotide).
  • Preoperative imaging (CT, angiography, endoscopic ultrasonography, octreotide scanning) and surgical exploration with intraoperative ultrasonography for tumor localization.

Main Results:

  • Aggressive surgical excision is indicated for most patients, offering potential cure for insulinomas, gastrinomas, and some other islet cell tumors.
  • Medical therapies for unresectable malignant disease currently have limited efficacy.
  • Newer techniques in localization, surgery, and nonoperative treatments show promise for improved cure rates and palliation.

Conclusions:

  • A multidisciplinary approach involving early diagnosis, precise localization, and surgical resection is key to managing islet cell tumors.
  • While challenging, surgical cure is achievable for a significant number of patients.
  • Ongoing advancements in diagnostic and therapeutic modalities offer hope for better patient outcomes.