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Idiopathic polyneuropathy in Alaskan malamutes
K G Braund1, A Shores, C T Lowrie
1Spontaneous Neuromuscular Disease Program, Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, AL 36849-5525, USA.
Journal of Veterinary Internal Medicine
|July 1, 1997
Summary
A progressive polyneuropathy affects young Alaskan Malamutes, causing hind limb weakness and nerve damage. This study identifies it as a distinct distal sensorimotor polyneuropathy in the breed.
Area of Science:
- Veterinary Neurology
- Canine Pathology
Background:
- Progressive polyneuropathies can significantly impact canine mobility and quality of life.
- Alaskan Malamutes may be predisposed to specific neurological conditions.
Purpose of the Study:
- To describe the clinical and morphologic features of a progressive polyneuropathy in young adult Alaskan Malamutes.
- To differentiate this condition from other known polyneuropathies in the breed.
Main Methods:
- Clinical examination and electrophysiologic testing (electromyography) were performed.
- Skeletal muscle and peripheral nerve tissues were examined morphologically and ultrastructurally.
Main Results:
- Clinical signs included progressive paraparesis, gait abnormalities, exercise intolerance, and tetraplegia.
- Electromyography showed diffuse abnormalities in limb muscles.
- Pathologic findings revealed neurogenic muscle atrophy, nerve fiber loss, and axonal/myelin changes suggestive of distal sensorimotor polyneuropathy.
Conclusions:
- The described condition is a progressive, distal sensorimotor polyneuropathy in Alaskan Malamutes.
- This idiopathic polyneuropathy is distinct from the previously described hereditary form in Norwegian Alaskan Malamutes.