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Related Experiment Videos

CD44 in inflammation and metastasis

J Lesley1, R Hyman, N English

  • 1Department of Cancer Biology, The Salk Institute, San Diego, California 92186, USA.

Glycoconjugate Journal
|August 1, 1997
PubMed
Summary
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CD44, a cell surface receptor, binds hyaluronan (HA) and its function is regulated by cell-specific post-translational modifications. These modifications impact HA binding, ligand specificity, and roles in inflammation and cancer metastasis.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • CD44 is a primary cell surface receptor for hyaluronan (HA).
  • CD44's interaction with HA is regulated by cellular context and post-translational modifications, not solely by expression levels.
  • These modifications significantly influence CD44's HA binding function and ligand specificity.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of CD44 function, particularly its interaction with HA.
  • To investigate the role of post-translational modifications in CD44-mediated biological processes.
  • To explore the involvement of CD44 in inflammation and cancer progression.

Main Methods:

  • Analysis of CD44 expression patterns and isoforms.
  • Investigation of post-translational modifications (N-linked, O-linked, glycosaminoglycan additions).

Related Experiment Videos

  • Assays to determine HA binding activity and ligand specificity.
  • Studies on CD44's role in leukocyte interactions and cancer cell behavior.

    • Main Results:

    • CD44 binding activity is modulated by cellular regulation and extensive post-translational carbohydrate modifications.
    • These modifications affect HA binding, extracellular matrix interactions (fibronectin, collagen), and growth factor sequestration.
    • CD44/HA interactions are implicated in leukocyte rolling and activation.
    • Altered CD44 expression patterns are associated with various cancers and metastatic potential, though correlations vary.

    Conclusions:

    • Post-translational modifications are key regulators of CD44 function, impacting HA binding and broader biological roles.
    • CD44 plays a role in inflammatory processes and cancer, potentially through altered HA recognition and novel ligand interactions.
    • Further research is needed to fully understand CD44's diverse functions in malignancy and other biological contexts.