Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic trafficking through astrocytic gap junctions

C Giaume1, A Tabernero, J M Medina

  • 1INSERM U114, Collège de France, Paris. giaume@infobiogen.fr

Glia
|September 23, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

geno<sup>5</sup>mC: A Database to Explore the Association between Genetic Variation (SNPs) and CpG Methylation in the Human Genome.

Journal of molecular biology·2020
Same author

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer's disease.

Cell death and differentiation·2016
Same author

Introduction to the special issue: Dynamic and metabolic interactions between astrocytes and neurons.

Neuroscience·2016
Same author

Relearning of Activities of Daily Living: A Comparison of the Effectiveness of Three Learning Methods in Patients with Dementia of the Alzheimer Type.

The journal of nutrition, health & aging·2016
Same author

The shape of dementia: new measures of morphological complexity in event-related potentials (ERP) and its application to the detection of Alzheimer's disease.

Medical & biological engineering & computing·2015
Same author

The role of connexin43-Src interaction in astrocytomas: A molecular puzzle.

Neuroscience·2015

Astrocytes, connected by gap junctions, facilitate brain metabolism by sharing energy substrates like glucose between blood circulation and neurons. Inhibiting these connections disrupts this vital nutrient distribution.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Astrocytes are glial cells situated between blood vessels and neurons.
  • They play a crucial role in brain metabolism and energy substrate supply.
  • Astrocytes communicate via gap junctions, enabling direct intercellular exchange.

Purpose of the Study:

  • To investigate the role of astrocyte gap junctions in brain metabolism.
  • To understand how intercellular communication influences energy substrate distribution.

Main Methods:

  • Utilized primary astrocyte cultures.
  • Manipulated gap junctional permeability using uncoupling agents.
  • Assessed glucose uptake and utilization.

Main Results:

Related Experiment Videos

  • Inhibition of gap junction permeability altered intercellular diffusion of glucose.
  • Astrocyte gap junctions are involved in the utilization and uptake of glucose.
  • Intercellular pathways formed by coupled astrocytes impact metabolic processes.

Conclusions:

  • Astrocyte gap junctions are critical for the brain's metabolic network.
  • Intercellular communication via gap junctions facilitates the distribution of energy substrates.
  • Targeting astrocyte gap junctions could influence brain energy metabolism.