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Study of correlations between fine structure of bonded layer and affinity properties of silicas with attached cyclic
P G Mingalyov1, N V Orishchenko, Fadeev AYu
1Chemistry Department, Moscow State University, Vorob yovy Gory, Russia.
Journal of Chromatography. A
|August 15, 1997
Abstract:
The cyclic oligopeptides bacitracin A and gramicidin-S were immobilized on epoxy-, tosyloxy- and halogenoaklyl-activated silicas. The sorbents obtained were tested for affinity binding of proteinases. The effects of spacer length, ligand loading and the character of ligand attachment (one- or poly-site) on the biospecific characteristics have been studied.