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Production of D-ribose by fermentation
1Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
Applied Microbiology and Biotechnology
|August 1, 1997
Summary
Recent advances in D-ribose fermentation yield over 90 g/L. This review covers methods, mutant strains, and applications for synthesizing D-ribose, a key component in antiviral and anticancer drugs.
Area of Science:
- Biotechnology
- Biochemistry
- Microbial Fermentation
Background:
- D-ribose is a pentose sugar crucial for synthesizing antiviral and anticancer drugs.
- Its production via fermentation has gained significant attention due to its therapeutic applications.
Purpose of the Study:
- To review historical and recent methods for D-ribose synthesis.
- To focus on advancements in D-ribose fermentation.
- To discuss mutant strains and their genetic basis for enhanced D-ribose production.
Main Methods:
- Review of literature on D-ribose synthesis.
- Analysis of fermentation techniques for D-ribose production.
- Examination of genetic and biochemical strategies for mutant strain development.
Main Results:
- D-ribose fermentation yields exceeding 90 g/L have been achieved.
- Transketolase-deficient mutants show enhanced D-ribose productivity.
- Specific biochemical and genetic rationales underpin mutant selection and optimization.
Conclusions:
- Fermentation is a highly effective method for D-ribose production.
- Optimized mutant strains offer significant improvements in yield.
- D-ribose has diverse industrial and academic applications, particularly in pharmaceuticals.