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Factors inducing posttransplant erythrocytosis
V Lezaić1, L J Djukanović, V Pavlović-Kentera
1Department of Nephrology, University Clinical Center Pasterova 2, Beograd 11000, Yugoslavia.
European Journal of Medical Research
|September 25, 1997
Summary
Post-renal transplant erythrocytosis (PTE) is linked to elevated erythropoietin (Epo) and Burst Promoting Activity (BPA), potentially driven by higher cyclosporine levels. This suggests increased sensitivity of erythroid progenitors contributes to sustained erythropoiesis after kidney transplantation.
Area of Science:
- Nephrology
- Hematology
- Immunology
Background:
- Erythrocytosis can occur after renal transplantation.
- Factors influencing post-transplant erythrocytosis (PTE) require further investigation.
Purpose of the Study:
- To analyze factors contributing to erythrocytosis in renal transplant recipients.
- To compare patients with PTE to those with normal hemoglobin levels post-transplantation.
Main Methods:
- Compared 9 patients with PTE to 9 control patients 2 years post-transplantation.
- Measured serum erythropoietin (Epo) levels, observed/expected (O/E) Epo ratio, and erythroid progenitor growth (BFU-E).
- Assessed Burst Promoting Activity (BPA) and whole blood cyclosporine levels.
Main Results:
- PTE patients had significantly higher mean serum Epo levels (33.9 vs. 21.6 mU/ml) and a higher O/E Epo ratio (10.0 vs. 1.05).
- Spontaneous growth of Burst-forming unit-erythroid (BFU-E) was observed in 5/9 PTE patients (p=0.04).
- Higher Burst Promoting Activity (BPA) and elevated whole blood cyclosporine levels were noted in PTE patients.
Conclusions:
- Sustained erythropoiesis leading to PTE may result from increased Epo and BPA levels.
- Elevated cyclosporine levels might increase erythroid progenitor sensitivity, contributing to PTE.
- These findings highlight the complex interplay of factors in post-transplant erythrocytosis.