Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between mivacurium and pancuronium

S Kim1, J C Shim, D W Kim

  • 1Department of Anaesthesiology, College of Medicine, Hanyang University Hospital, Seoul, Korea.

British Journal of Anaesthesia
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36  TeV with the ATLAS Detector at the LHC.

Physical review letters·2025
Same journal

Audit of procedural sedation complications using a novel digital application.

British journal of anaesthesia·2026
Same journal

Social deprivation and morbidity and mortality after surgery. Comment on Br J Anaesth 2025; 135: 1193-1202.

British journal of anaesthesia·2026
Same journal

Single-dose intraoperative methadone and QTc interval: a prospective observational cohort investigation.

British journal of anaesthesia·2026
Same journal

Postoperative outcomes in older patients with postoperative delirium in the UK: timing of postoperative delirium screening in the SNAP-3 study. Comment on Br J Anaesth 2026; 136: 1578-87.

British journal of anaesthesia·2026
Same journal

Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia.

British journal of anaesthesia·2026
Same journal

Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis.

British journal of anaesthesia·2026
See all related articles

This study found that combining mivacurium and pancuronium demonstrates a synergistic interaction, enhancing neuromuscular blockade. Following pancuronium administration, mivacurium exhibited a prolonged duration of action.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Clinical Medicine

Background:

  • Neuromuscular blocking agents are crucial in anesthesia.
  • Understanding drug interactions is vital for optimizing patient care.
  • Mivacurium and pancuronium are commonly used neuromuscular blockers.

Purpose of the Study:

  • To compare the dose-response relationships of mivacurium and pancuronium.
  • To investigate the interaction between mivacurium and pancuronium.
  • To analyze the synergistic effects of combining these neuromuscular blockers.

Main Methods:

  • Studied 70 adult patients under nitrous oxide-fentanyl-propofol anesthesia.
  • Determined dose-response curves using probit analysis.
  • Employed isobolographic and fractional analyses to assess drug interactions.

Related Experiment Videos

Main Results:

  • Established ED95 and ED50 values for mivacurium and pancuronium.
  • Demonstrated a synergistic interaction between mivacurium and pancuronium.
  • Found that mivacurium's duration of action was prolonged after pancuronium administration.

Conclusions:

  • The combination of mivacurium and pancuronium exhibits synergistic effects.
  • Mivacurium acts as a longer-acting agent when administered after pancuronium.
  • This synergistic interaction has implications for anesthetic practice and neuromuscular blockade management.