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Improved detection of recurrent bladder cancer using the Bard BTA stat Test
M F Sarosdy1, M A Hudson, W J Ellis
1Division of Urology, University of Texas Health Science Center, San Antonio 78284-7845, USA.
Objectives:
To evaluate the BTA stat Test in the detection of recurrent bladder cancer.
Methods:
Sensitivity and specificity were determined using frozen voided urine samples from patients with recurrent bladder cancer, volunteers, patients with nonurologic conditions, and patients with a history of bladder cancer but free of disease. Results of cytology and the original BTA Test were compared with the sensitivity of the BTA stat Test in a large subgroup of the patients with cancer.
Results:
The BTA stat Test detected 147 (67%) of 220 recurrent cancers. For those urine samples with previous cytologic and BTA Test results available, cytology had a sensitivity of 23%, the BTA Test 44%, and the BTA stat Test 58% for detection of recurrent cancer (P < 0.001, stat versus cytology). The specificity of the BTA stat Test was 72% for benign genitourinary disease and 95% in healthy volunteers.
Conclusions:
The BTA stat Test has high sensitivity and is significantly superior to voided urine cytologic analysis in the detection of recurrent bladder cancer.