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[Clinical assessment of myocardial protection with blood-GIK solution]
Insights
Blood GIK solution offers superior myocardial protection during coronary bypass surgery compared to GIK alone or Young+GIK. This method improved cardiac index and reduced cardiac enzyme levels post-operation.
Area of Science:
- Cardiology
- Cardiac Surgery
- Cardiovascular Research
Background:
- Myocardial protection strategies are crucial in coronary bypass surgery.
- Different methods including GIK, Young+GIK, and blood GIK have been employed since 1984.
- Evaluating the efficacy of blood GIK is essential for optimizing surgical outcomes.
Purpose of the Study:
- To compare the effectiveness of myocardial protection using blood GIK solution against GIK alone and Young+GIK.
- To demonstrate the advantages of blood GIK in coronary bypass surgery.
- To assess postoperative hemodynamic changes and serum enzyme levels.
Main Methods:
- Eighty-three patients undergoing coronary bypass surgery were divided into three groups.
- Group I received GIK alone, Group II received Young+GIK, and Group III received Young+blood GIK.
- Postoperative serum enzymes (MB-CPK) and hemodynamic parameters (cardiac index) were analyzed.
Main Results:
- Group III (Young+blood GIK) showed a significantly higher cardiac index at 24 hours post-operation (p < 0.05).
- The peak MB-CPK levels in Group III were significantly lower than in Group I and Group II (p < 0.01).
- Blood GIK demonstrated superior myocardial protection compared to the other methods.
Conclusions:
- Blood GIK solution provides enhanced myocardial protection in coronary bypass surgery.
- This method leads to better hemodynamic recovery and reduced myocardial damage.
- The findings support the use of blood GIK as a preferred myocardial protection strategy.
Abstract:
Since Jan, 1984, three different types of myocardial protection have been tried in coronary bypass surgery. These are GIK (1984. 1-1984. 12), Young+GIK (1985. 1-1986. 8), and blood GIK (1986. 9-until present). In this study we tried to demonstrate the advantage of myocardial protection induced with blood GIK solution in comparison with that with GIK alone or Young + GIK. (Materials and methods) Eighty-three patients undergone coronary bypass surgery in that period, were evaluated and divided into three groups: Group I had myocardial protection with GIK alone in 24 patients, group II had myocardial protection with Young + GIK in 28 patients, and group III had myocardial protection with Young + blood GIK in 31 patients. Among these groups, the changes of serum enzymes and hemodynamics in postoperative period were compared. (Results) In the hemodynamic changes, cardiac index at 24 hours after operation in group III, was higher than that in the other two groups (p < 0.05). The peak value of MB-CPK in all groups appeared 12 hours after operation, however, 21.9 +/- 19.72 IU/ml in group III was significantly lower than 33.4 +/- 25.5 in group I, or 36.9 +/- 26.8 in group II (p < 0.01). The results demonstrates that the myocardial protection induced with blood GIK are superior to these with the other two method.