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Enhanced pulmonary accumulation of liposomal amphotericin B (AmBisome) in acute liver transplant failure
1Klinikum Grosshadern, III Medical Clinic, University of Munich, Germany.
The Journal of Antimicrobial Chemotherapy
|August 1, 1997
Abstract:
Plasma and tissue concentrations of amphotericin B were determined in a patient treated with liposomal amphotericin B during liver transplant failure. A cumulative rise in amphotericin B plasma concentrations was observed accompanied by an enhanced pulmonary deposition of the drug. Failure of the liver as a major component of the reticuloendothelial system may cause elevated plasma concentrations of liposomal amphotericin B and may consequently enhance deposition of liposomes in the lungs as a substitutive clearing organ.