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Desmosomes and disease

¹School of Biological Sciences, University of Manchester, UK.

Histology and Histopathology

|September 26, 1997

Summary

This summary is machine-generated.

Desmosomes, crucial cell adhesion structures, are implicated in blistering diseases like pemphigus and skin cancer. Research identifies specific desmosomal glycoproteins as targets in these conditions and potential causes of inherited skin disorders.

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Area of Science:

Cell biology
Dermatology
Molecular genetics

Background:

Desmosomes are vital intercellular junctions in epithelial tissues.
Significant advancements have been made in understanding desmosome components and their functions.

Purpose of the Study:

To review the current knowledge of desmosomes and their associated glycoproteins.
To highlight the role of desmosomal components as autoantigens in blistering diseases.
To explore the involvement of desmosomes in cancer and inherited skin disorders.

Main Methods:

Molecular cloning of desmosomal glycoproteins.
Immunological studies identifying autoantibody targets.
Review of evidence linking desmosomes to cancer metastasis and genetic skin conditions.

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Main Results:

Desmoglein 1 and desmoglein 3 are identified as autoantibody targets in pemphigus foliaceus and pemphigus vulgaris.
Desmocollin 1 is implicated as a key antigen in IgA pemphigus.
Evidence suggests desmosomes play a role in inhibiting cancer invasion and metastasis.
Mutations in desmosomal glycoprotein genes may cause inherited palmoplantar keratoderma.

Conclusions:

Desmosomal glycoproteins are critical targets in autoimmune blistering diseases.
Desmosomes are important in maintaining epithelial integrity and preventing cancer spread.
Further research into desmosome function is crucial for understanding and treating various skin diseases.