A systematic method for evaluating the potential viability of local vaccine producers

Area of Science:

• Public Health
• Biotechnology
• Health Systems Strengthening

Background:

• Global vaccine production is widespread (>55 countries), yet many facilities struggle with reliable supply chains for existing and novel vaccines.
• Ensuring a consistent vaccine supply is crucial for global health security and disease prevention efforts.

Purpose of the Study:

• To identify critical success factors for vaccine production viability.
• To develop a framework for assessing vaccine manufacturers' potential and investment needs.
• To guide governments and donors in strategic investments for local vaccine production.

Main Methods:

• Analysis of characteristics of successful vaccine producers to define seven critical viability elements.
• Development of specific indicators for each viability element.
• Assessment of 31 vaccine manufacturers based on these indicators and associated investment costs.

Main Results:

• Three distinct groupings of manufacturers emerged: 'viable' (strong across all elements), 'potentially viable' (capable of meeting national needs with structural improvements), and 'low probability' (weak across all elements).
• Identified weaknesses in viability indicators directly correlate with necessary investments for improvement.
• The assessment framework provides a clear system for evaluating manufacturer potential.

Conclusions:

• A structured approach to evaluating vaccine production facilities is essential for effective resource allocation.
• Investment in 'potentially viable' manufacturers requires a focus on enhancing management structures for change.
• This framework supports informed decision-making for strengthening local vaccine production capacity globally.