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X-ray phototherapy for canine brain masses
A Norman1, M Ingram, R G Skillen
1Department of Radiation Oncology, UCLA School of Medicine 90095-1721 USA. anorman@ucla.edu
Radiation Oncology Investigations
|January 1, 1997
Summary
This study shows that a novel radiation therapy using iodinated contrast media and a modified CT scanner (CTRx) significantly extended survival in dogs with brain tumors. Treated dogs survived a median of 230 days, outperforming conventional radiation and untreated controls.
Area of Science:
- Veterinary Oncology
- Radiation Oncology
- Medical Imaging
Background:
- Brain tumors are a significant concern in pet dogs.
- Conventional treatments for canine brain tumors have limited efficacy.
- Novel therapeutic approaches are needed to improve outcomes.
Purpose of the Study:
- To evaluate the efficacy of a new radiation therapy technique for canine brain tumors.
- To assess the impact of iodinated contrast media and a modified CT scanner (CTRx) on tumor treatment.
- To compare survival rates with historical controls and conventional radiotherapy.
Main Methods:
- 47 dogs with diagnosed brain masses underwent CT scans; 12 had necropsies.
- Tumors were treated using a modified CT scanner (CTRx) with iodinated contrast media.
- 26 dogs received ≥6 weekly treatments of ~5.6 Gy/fraction, totaling a median of 39 Gy.
Main Results:
- Dogs receiving CTRx therapy survived a median of 230 days.
- This survival rate is significantly greater than untreated historic controls (6-13 days).
- Survival also compared favorably to dogs treated with conventional cobalt-60 radiation (150 days).
Conclusions:
- CTRx therapy, utilizing iodinated contrast media, offers a promising treatment for canine brain tumors.
- This approach demonstrates superior survival outcomes compared to conventional whole-brain radiation and untreated controls.
- Further investigation into this innovative radiation technique is warranted for veterinary oncology.